منابع مشابه
DEAD-box proteins
How are they identified? Originally, these proteins were identified by genetic approaches. Comparison of their amino acid sequences revealed a high degree of conservation of eight different motifs. They are present in a core region that is flanked by 5′ and 3′ external sequences of various length. The systematic sequencing of genomes, reverse genetics and genetic methods have revealed the wides...
متن کاملmRNA export: Travelling with DEAD box proteins
Recent studies have shown that the putative RNA helicase protein UAP56 and its yeast homologue Sub2p are not only involved in pre-mRNA splicing but also required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene.
متن کاملRNA Chaperones Exist and DEAD Box Proteins Get a Life
The RNA chaperone hypothesis suggests the existence of proteins that resolve misfolded RNA structures in vivo. A recent study has found an RNA-dependent ATPase that functions in this manner.
متن کاملSpliceosome assembly: The unwinding role of DEAD-box proteins
Splicing factors belonging to the DEAD-box superfamily can affect RNA conformation in vitro. These proteins may control the dynamic changes in RNA base-pairing interactions during spliceosome assembly.
متن کاملmRNA Export: RNP Remodeling by DEAD-Box Proteins
The DEAD-box protein Dbp5 was thought to remodel ribonucleoproteins and displace proteins from these complexes in an ATP-dependent fashion to allow for mRNA export from the nucleus. A recent study on Dbp5 shows, however, that its ADP-bound form may also perform an important function in displacing export factors from mRNA.
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ژورنال
عنوان ژورنال: Current Biology
سال: 2000
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(00)00857-5